Anti-inflammatory effects of black cumin essential oil on liver and lung tissue
The results of the researchers of the Department of Clinical Biochemistry of Tarbiat Modares University showed that black cumin essential oil has protective effects on both liver and lung tissues against damage caused by inflammatory and oxidative reactions.
Infection or sepsis accounts for a high percentage of deaths. In this disease, proinflammatory and anti-inflammatory cytokines play an important role in systemic inflammatory responses.
Inflammation is involved directly in the development of the disease not only by activating the immune system but also by cyclooxygenase-2 (COX-2). Active radicals produced in the inflammatory process activate the transcription factor, which in turn increases the level of factors involved in the inflammatory process, including cytokines and COX2.
Due to the important role of COX2, nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat inflammation as well as cancer.
Dr. Faezeh Fatemi, who conducted and presented this research in the form of her specialized dissertation in the field of clinical biochemistry, added: Considering the side effects of NSAIDs, the use of medicinal plants with anti-inflammatory properties such as black cumin to treat and reduce the effects of Inflammation has been noted.
He further referred to the irradiation of black cumin seeds and said about the objectives of this study: One of the ways to preserve black cumin seeds as a medicinal plant is its irradiation, which unfortunately so far little study has been done to preserve the pharmacological properties of black cumin after No irradiation has taken place.
In this study, the effect of hydroalcoholic extract and essential oil extracted from irradiated and irradiated black cumin seeds with gamma rays on the parameters involved in inflammation and oxidative damage of liver and lung tissue in the experimental inflammatory model of CLP in mice was studied.
Explaining the results of this study, Dr. Fatemi said: The results of this study showed that inflammatory parameters in liver, lung and plasma tissues as well as expression of COX2 gene in liver tissue induced in the CLP inflammatory model in mice treated with cumin essential oil significantly. Dari has decreased.
Factors involved in tissue oxidative damage such as lipid peroxidation, glutathione, and myeloperoxidase are also reduced in the liver and lung tissues of essential oil-treated mice, while the hydroalcoholic extract of black cumin has no effect.
In confirmation of these results, histopathological studies showed that the indicators of pathological damage in liver and lung tissue, which is significantly seen in the sepsis group, are reduced in the groups treated with cumin essential oil.
He concluded: Histopathological and biochemical results of this study indicate that the essence of black cumin and not hydroalcoholic extract has protective effects on both liver and lung tissues against damage caused by inflammatory and oxidative reactions.
It seems that part of this mechanism is due to the effect of essential oil extracted from black cumin on the activity of inflammatory parameters as well as factors involved in oxidative damage. In addition, these effects are preserved in the essential oil of irradiated cumin.