Chamomile is very effective in reducing seizures
Total chamomile extract is effective in inhibiting seizures when co-administered with pentylenetetrazole (PTz).
Dr. Abolfazl Karami in his dissertation entitled Investigation of anticonvulsant effects of total extract of 4 medicinal plants (valerian, tea grass, chamomile, leaf odor) on convulsions caused by penicillin tetrazole in mice, has stated: Total extract of valerian At doses of 500 and 300 mg / kg half an hour before injection (PTz), it is able to delay the onset of seizures and reduce the rate and mortality of diazepam.
Studies on the anticonvulsant mechanism of action of this plant extract show that it has an effect on increasing the amount of GABA in the brain, this is probably due to the statistical increase in GABA release and inhibition of the degradation of this neurotransmitter.
Research of this dissertation under the guidance of Dr. Abbas Kobriaeizadeh, Dr. Mohammad Reza Monsef Esfahani by evaluating the total extract of four plants with doses of 100, 300, 500, 700, mg / kg intraperitoneally simultaneously 15, 30, 60 minutes before Injection (PTz) was injected and the parameters and mortality rate were evaluated.
These results show that whole extract of tea grass in the mentioned doses did not have a significant effect on delaying seizures but reduced the incidence of mortality with diazepam administration.
It is worth mentioning that tea herb is known as an antidepressant compound in different countries.
These results add: The total extract of bo leaf in the doses used has no effect on the time of onset of seizures due to (PTz) in concomitant administration as well as in administration at different time intervals and does not reduce mortality.
Studies show that the whole extract of chamomile and azulene has an antioxidant effect.
Since one of the mechanisms that has been proposed today in the pathophysiology of diseases of the central nervous system is the presence of free radicals, so any compound that has antioxidant effects can be effective in preventing these disorders.
In the epileptogenic process, the excitatory amino acid glutamate can increase the amount of cytosolic calcium in neurons through NMDA and non-NMDA receptors.
Also, increasing the stimulation of glutamate receptors increases the amount of free radicals in brain cells.
Researchers have found that chamomile extract and azulene can inhibit lipid peroxidation in rat liver cells.