Thyme extract is effective in preventing seizures
The results of a study showed that thyme hydroalcoholic extract has anticonvulsant effect, and its exact mechanisms need to be studied further on different animal models.
The results of research by Dr. Ardeshir Arzi, Dr. Saleh Zahedi Asl and Dr. Davood Fallahzadeh, researchers in the Department of Pharmacology and Toxicology, Ahwaz University of Medical Sciences, who investigated It is the central nervous system that many people in the community suffer from.
Since synthetic anticonvulsant drugs cause many adverse side effects in the patient, so herbal medicines can be widely used in seizure control.
In this study, the effect of thyme hydroalcoholic extract on the prevention of nicotine-induced seizures (5 mg / kg) in small white mice was investigated.
The results of different doses (100, 200, 400, 600, 800, 1000 mg / kg) showed that thyme extract has a dose-dependent effect and the dose of 800 mg / kg has the maximum effect on increasing the onset time of seizures and reducing Severity and duration of seizures.
These results add: Although the dose of 1000 mg / kg of the extract showed a good effect by increasing the onset time of seizures and reducing the severity and duration of leakage, but due to the high percentage of mortality, this dose was not considered appropriate.
In the continuation of this study, the effect of time interval between injection of appropriate dose of extract (800 mg / kg) and nicotine, time intervals of 0, 15, 30, 45 and 60 minutes was selected. The results of seizure onset and seizure severity at application of 800 mg / kg of extract at 0, 15, 30, 45, 60 minutes before nicotine injection were significantly increased and decreased, respectively, while the use of extract only in Time 0, 15.30 minutes before nicotine injection significantly reduced seizure duration.
According to the results of this study, the maximum effect of thyme extract on different quantities was measured in the time interval of 15 and 30 minutes between the injection and nicotine injection.
The researchers noted that the effect of nicotine on the central nervous system is inhibitory and stimulatory, which can be inhibited by the inhibitory neurotransmitter of the spinal cord, glycine, and its stimulatory effect by stimulating the psycho-motor part of the brain. .
Accordingly, the mechanism of action of thyme from seizures due to nicotine use can be through inhibition of one or both of the above mechanisms or anticonvulsant mechanism, which achieves a definite result requires extensive studies on various animal models.